Dermot McGovern 医学博士, 理科博士,皇家学院医生(英国UK) 消化内科炎症性肠病和免疫学研究所转化医学主任

研究重点 识别增加易感性和影响的溃疡性结肠炎（UC）和克罗恩氏病的自然史性遗传变异体。研究兴趣是使用两个临床因素和生物标志物预测UC和克隆氏病疗法的结果和反应。 研究贡献 第一个全基因组IBD的关联扫描，并联合撰写并发表了大量论文鉴定等易感基因。在使用遗传，血清学和临床指标的组合发展IBD风险模型研究中起领导地位。 目前的研究包括： 炎症性肠病IBD 易感基因进一步鉴定 炎症性肠病IBD 表型/基因型相关性 炎症性肠病IBD易感基因功能的影响 出版物精选 . Ippoliti A, Devlin S, Mei L, Yang H, Papadakis KA, Vasiliauskas EA, McGovern DP, Abreu MT, Melmed G, Shaye O, Enayati P, Chen G, Choi J, Taylor K, Landers CJ, Rotter JI, Targan SR:先天免疫和适应性免疫的变化组合增加克罗恩病纤维狭窄的可能性。Inflamm. Bowel Dis., , 2009 . Dubinsky MC, Mei L, Friedman M, Dhere T, Haritunians T, Hakonarson H, Kim C, Glessner J, Targan SR, McGovern DP, Taylor KD, Rotter JI:在儿科炎症性肠病的抗TNFα治疗反应中全基因组关联（GWA）预测。. Inflamm. Bowel Dis., , 2009 . Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D, Western Regional Alliance for 儿科 IBD, Silber G, Wrobel I, Quiros A, International IBD Genetics Consortium, Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmuda MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, RegueiroMD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Belgian-French IBD Consortium, Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwillam R, Tremelling M, Delukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ, Heyman MB, Ferry GD, Kirschner B, Lee J, Essers J, Grand R, Stephens M, Levine A, Piccoli D, Van Limbergen J, Cucchiara S, Monos DS, Guthery SL, Denson L, Wilson DC, Grant SF, Daly M, Silverberg MS, Satsangi J, Hakonarson H:五个新的基因位点常见的变异与炎症性肠疾病的早发性相关。 Nat. Genet., 41(12): 1335-40, 2009 . Silverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, Achkar JP, Goyette P, Scott R, Xu W, Barmada MM, Klei L, Daly MJ, Abraham C, Bayless TM, Bossa F, Griffiths AM, Ippoliti AF, Lahaie RG, Latiano A, Paré P, Proctor DD, Regueiro医学博士, Steinhart AH, Targan SR, Schumm LP, Kistner EO, Lee AT, Gregersen PK, Rotter JI, Brant SR, Taylor KD, Roeder K, Duerr RH:通过全基因组关联研究发现染色体1p36和12q15溃疡性结肠炎风险基因位点。. Nat. Genet.更正：, 41(6): 762, 2009 McGovern DP, Rotter JI, Mei L, Haritunians T, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mengesha E, King L, Pressman S, Targan SR, Taylor KD:克罗恩病IL23/ IL17途径基因的遗传上位性. Inflamm. Bowel Dis., 15(6): 883-9, 2009